Hypersensitivity to naproxen, ibuprofen, aspirin or other NSAIDs/analgesics. History of upper GI bleeding or perforation related to previous NSAIDs therapy. Severe heart, hepatic or renal failure. Last trimester of pregnancy.
Diminished utility as diagnostic signs. Decrease platelet aggregation & prolong bleeding time. Patients suffering from, or w/ previous history of bronchial asthma. Monitor adverse events in patients w/ long-term NSAID treatment. Not to be used during 1st 2 trimester of pregnancy. Avoid use during lactation. Risk of ductus arteriosus closure in fetus.
May increase risk of renal impairment w/ ACE inhibitors. Reduced antihypertensive effect of antihypertensives. May exacerbate cardiac failure, reduce GFR & increase plasma glycoside levels w/ cardiac glycosides. Increased risk of GI ulceration or bleeding w/ corticosteroids.
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